Allergy, asthma, inflammatory, and autoimmune diseases can all contribute to neuroinflammation, a complex interplay between the immune system and the nervous system. Neuroinflammation can lead to a variety of neurological issues, and understanding the link between these conditions is crucial for effective treatment.  Acupuncture can modulate inflammation, potentially through the inflammatory reflex and neuroimmune pathways. It may help reduce inflammation in various conditions, including rheumatoid arthritis, by influencing factors like the vagus nerve and its impact on immune cell activity. Studies suggest acupuncture can alleviate pain and neuroinflammation, potentially by influencing opioid receptors and reducing the excitability of peripheral neurons.  Rheumatology and neuroinflammation are connected because chronic peripheral inflammation, common in rheumatic diseases like rheumatoid arthritis (RA), can lead to neuroinflammation in the central nervous system (CNS). This neuroinflammation can contribute to neuropsychiatric symptoms, such as depression and cognitive impairment, that are often observed in RA patients. Acupuncture has demonstrated anti-inflammatory effects, including reducing neuroinflammation, a key process in various neurological disorders. Studies suggest that acupuncture can modulate immune cell activity and cytokine expression, ultimately reducing inflammatory responses in the brain. Specifically, acupuncture has been shown to inhibit the activation of NLRP3 inflammasome, a major contributor to neuroinflammation. Acupuncture can modulate the inflammatory response by influencing nerve pathways that either suppress or promote inflammation, depending on where, when, and how it is used. It does this by stimulating various neuro-immune pathways, including the cholinergic anti-inflammatory pathway, vagus-adrenal medulla-dopamine pathway, sympathetic pathways, and the hypothalamus-pituitary-adrenal axis, ultimately affecting immune cells and reducing inflammatory cytokines. Acupuncture can modulate inflammatory responses through a variety of mechanisms, including activating specific nerve pathways, influencing the activity of immune cells, and regulating cytokines. Studies have shown that acupuncture can both suppress and promote inflammation, depending on the specific application parameters such as stimulation site, intensity, and timing. This can lead to anti-inflammatory effects in conditions like sepsis and inflammatory bowel disease, as well as modulating the immune system in response to cancer therapy.    This is for informational purposes only. For medical advice or diagnosis, consult a professional.